The etiologic role of HPV infection in oropharynx cancer has now been firmly established. 1, 2 While the epidemiology, natural history and molecular biology of the HPV infection and subsequent development of cancers in the genital tract have been extensively studied in the past, there are many unknowns in oral HPV infection and its role in development of oropharynx cancer. Human papillomavirus (HPV) infection accounts for approximately 5.2% of the worldwide human cancer burden including the cancers of the anus, genital tract and oropharynx.
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